Ribonuclease from Bacillus Acts as an Antiviral Agent against Negative- and Positive-Sense Single Stranded Human Respiratory RNA Viruses
Identifieur interne : 000E64 ( Main/Exploration ); précédent : 000E63; suivant : 000E65Ribonuclease from Bacillus Acts as an Antiviral Agent against Negative- and Positive-Sense Single Stranded Human Respiratory RNA Viruses
Auteurs : Raihan Shah Mahmud [Russie] ; Christin Müller [Allemagne] ; Yulia Romanova [Russie] ; Ahmed Mostafa [Allemagne, Égypte] ; Vera Ulyanova [Russie] ; Stephan Pleschka [Allemagne] ; Olga Ilinskaya [Russie]Source :
- BioMed Research International [ 2314-6133 ] ; 2017.
Abstract
Url:
DOI: 10.1155/2017/5279065
PubMed: 28546965
PubMed Central: 5435908
Affiliations:
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xml:lang="en" level="a" type="main">Ribonuclease from<italic> Bacillus</italic> Acts as an Antiviral Agent against Negative- and Positive-Sense Single Stranded Human Respiratory RNA Viruses</title><author><name sortKey="Shah Mahmud, Raihan" sort="Shah Mahmud, Raihan" uniqKey="Shah Mahmud R" first="Raihan" last="Shah Mahmud">Raihan Shah Mahmud</name><affiliation wicri:level="1"><nlm:aff id="I1">Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskaya Street 18, Kazan 420008, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskaya Street 18, Kazan 420008</wicri:regionArea><wicri:noRegion>Kazan 420008</wicri:noRegion></affiliation></author><author><name sortKey="Muller, Christin" sort="Muller, Christin" uniqKey="Muller C" first="Christin" last="Müller">Christin Müller</name><affiliation wicri:level="1"><nlm:aff id="I2">Institute of Medical Virology, Justus Liebig University, Schubert Street 81, 35392 Giessen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, Justus Liebig University, Schubert Street 81, 35392 Giessen</wicri:regionArea><wicri:noRegion>35392 Giessen</wicri:noRegion><wicri:noRegion>35392 Giessen</wicri:noRegion><wicri:noRegion>35392 Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Romanova, Yulia" sort="Romanova, Yulia" uniqKey="Romanova Y" first="Yulia" last="Romanova">Yulia Romanova</name><affiliation wicri:level="1"><nlm:aff id="I1">Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskaya Street 18, Kazan 420008, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskaya Street 18, Kazan 420008</wicri:regionArea><wicri:noRegion>Kazan 420008</wicri:noRegion></affiliation></author><author><name sortKey="Mostafa, Ahmed" sort="Mostafa, Ahmed" uniqKey="Mostafa A" first="Ahmed" last="Mostafa">Ahmed Mostafa</name><affiliation wicri:level="1"><nlm:aff id="I2">Institute of Medical Virology, Justus Liebig University, Schubert Street 81, 35392 Giessen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, Justus Liebig University, Schubert Street 81, 35392 Giessen</wicri:regionArea><wicri:noRegion>35392 Giessen</wicri:noRegion><wicri:noRegion>35392 Giessen</wicri:noRegion><wicri:noRegion>35392 Giessen</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Center of Scientific Excellence for Influenza Viruses, National Research Centre (NRC), El-Buhouth Street 87, Dokki, Cairo 12311, Egypt</nlm:aff><country xml:lang="fr">Égypte</country><wicri:regionArea>Center of Scientific Excellence for Influenza Viruses, National Research Centre (NRC), El-Buhouth Street 87, Dokki, Cairo 12311</wicri:regionArea><wicri:noRegion>Cairo 12311</wicri:noRegion></affiliation></author><author><name sortKey="Ulyanova, Vera" sort="Ulyanova, Vera" uniqKey="Ulyanova V" first="Vera" last="Ulyanova">Vera Ulyanova</name><affiliation wicri:level="1"><nlm:aff id="I1">Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskaya Street 18, Kazan 420008, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskaya Street 18, Kazan 420008</wicri:regionArea><wicri:noRegion>Kazan 420008</wicri:noRegion></affiliation></author><author><name sortKey="Pleschka, Stephan" sort="Pleschka, Stephan" uniqKey="Pleschka S" first="Stephan" last="Pleschka">Stephan Pleschka</name><affiliation wicri:level="1"><nlm:aff id="I2">Institute of Medical Virology, Justus Liebig University, Schubert Street 81, 35392 Giessen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, Justus Liebig University, Schubert Street 81, 35392 Giessen</wicri:regionArea><wicri:noRegion>35392 Giessen</wicri:noRegion><wicri:noRegion>35392 Giessen</wicri:noRegion><wicri:noRegion>35392 Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Ilinskaya, Olga" sort="Ilinskaya, Olga" uniqKey="Ilinskaya O" first="Olga" last="Ilinskaya">Olga Ilinskaya</name><affiliation wicri:level="1"><nlm:aff id="I1">Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskaya Street 18, Kazan 420008, Russia</nlm:aff><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Fundamental Medicine and Biology, Kazan Federal University, Kremlevskaya Street 18, Kazan 420008</wicri:regionArea><wicri:noRegion>Kazan 420008</wicri:noRegion></affiliation></author></analytic><series><title level="j">BioMed Research International</title><idno type="ISSN">2314-6133</idno><idno type="eISSN">2314-6141</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Bacillus pumilus</italic> ribonuclease (binase) was shown to be a promising antiviral agent in animal models and cell cultures. However, the mode of its antiviral action remains unknown. To assess the binase effect on intracellular viral RNA we have selected single stranded negative- and positive-sense RNA viruses, influenza virus, and rhinovirus, respectively, which annually cause respiratory illnesses and are characterized by high contagious nature, mutation rate, and antigen variability. We have shown that binase exerts an antiviral effect on both viruses at the same concentration, which does not alter the spectrum of A549 cellular proteins and expression of housekeeping genes. The titers of influenza A (H1N1pdm) virus and human rhinovirus serotype 1A were reduced by 40% and 65%, respectively. A preincubation of influenza virus with binase before infection significantly reduced viral titer after single-cycle replication of the virus. Using influenza A virus mini genome system we showed that binase reduced GFP reporter signaling indicating a binase action on the expression of viral mRNA. Binase reduced the level of H1N1pdm viral NP mRNA accumulation in A549 cells by 20%. Since the viral mRNA is a possible target for binase this agent could be potentially applied in the antiviral therapy against both negative- and positive-sense RNA viruses.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Glanville, N" uniqKey="Glanville N">N. Glanville</name></author><author><name sortKey="Johnston, S L" uniqKey="Johnston S">S. L. Johnston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pleschka, S" uniqKey="Pleschka S">S. Pleschka</name></author><author><name sortKey="Jaskunas, R" uniqKey="Jaskunas R">R. Jaskunas</name></author><author><name sortKey="Engelhardt, O G" uniqKey="Engelhardt O">O. G. Engelhardt</name></author><author><name sortKey="Zurcher, T" uniqKey="Zurcher T">T. Zürcher</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. 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Ilinskaya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ilinskaya, O N" uniqKey="Ilinskaya O">O. N. Ilinskaya</name></author><author><name sortKey="Shah Mahmud, R" uniqKey="Shah Mahmud R">R. Shah Mahmud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shah Mahmud, R" uniqKey="Shah Mahmud R">R. Shah Mahmud</name></author><author><name sortKey="Efimova, M" uniqKey="Efimova M">M. Efimova</name></author><author><name sortKey="Mostafa, A" uniqKey="Mostafa A">A. Mostafa</name></author><author><name sortKey="Ulyanova, V" uniqKey="Ulyanova V">V. Ulyanova</name></author><author><name sortKey="Ilinskaya, O" uniqKey="Ilinskaya O">O. Ilinskaya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Efimova, M A" uniqKey="Efimova M">M. A. Efimova</name></author><author><name sortKey="Shah Mahmud, R" uniqKey="Shah Mahmud R">R. Shah Mahmud</name></author><author><name sortKey="Zelenikhin, P V" uniqKey="Zelenikhin P">P. V. Zelenikhin</name></author><author><name sortKey="Sabirova, M I" uniqKey="Sabirova M">M. I. Sabirova</name></author><author><name sortKey="Kolpakov, A I" uniqKey="Kolpakov A">A. I. Kolpakov</name></author><author><name sortKey="Ilinskaya, O N" uniqKey="Ilinskaya O">O. N. Ilinskaya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muller, C" uniqKey="Muller C">C. Müller</name></author><author><name sortKey="Ulyanova, V" uniqKey="Ulyanova V">V. Ulyanova</name></author><author><name sortKey="Ilinskaya, O" uniqKey="Ilinskaya O">O. Ilinskaya</name></author><author><name sortKey="Pleschka, S" uniqKey="Pleschka S">S. Pleschka</name></author><author><name sortKey="Shah Mahmud, R" uniqKey="Shah Mahmud R">R. Shah Mahmud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dudkina, E" uniqKey="Dudkina E">E. Dudkina</name></author><author><name sortKey="Ulyanova, V" uniqKey="Ulyanova V">V. Ulyanova</name></author><author><name sortKey="Shah Mahmud, R" uniqKey="Shah Mahmud R">R. Shah Mahmud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shah Mahmud, R" uniqKey="Shah Mahmud R">R. Shah Mahmud</name></author><author><name sortKey="Ilinskaya, O N" uniqKey="Ilinskaya O">O. N. Ilinskaya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mostafa, A" uniqKey="Mostafa A">A. Mostafa</name></author><author><name sortKey="Kanrai, P" uniqKey="Kanrai P">P. Kanrai</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J. Ziebuhr</name></author><author><name sortKey="Pleschka, S" uniqKey="Pleschka S">S. Pleschka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neumann, G" uniqKey="Neumann G">G. Neumann</name></author><author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T. Watanabe</name></author><author><name sortKey="Ito, H" uniqKey="Ito H">H. Ito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoffmann, E" uniqKey="Hoffmann E">E. Hoffmann</name></author><author><name sortKey="Webster, R G" uniqKey="Webster R">R. G. Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cabrera Fuentes, H A" uniqKey="Cabrera Fuentes H">H. A. Cabrera-Fuentes</name></author><author><name sortKey="Aslam, M" uniqKey="Aslam M">M. Aslam</name></author><author><name sortKey="Saffarzadeh, M" uniqKey="Saffarzadeh M">M. Saffarzadeh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ullmer, W" uniqKey="Ullmer W">W. Ullmer</name></author><author><name sortKey="Semler, B L" uniqKey="Semler B">B. L. Semler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Faburay, B" uniqKey="Faburay B">B. Faburay</name></author><author><name sortKey="Richt, J A" uniqKey="Richt J">J. A. Richt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, C" uniqKey="Li C">C. Li</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z. Wang</name></author><author><name sortKey="Cao, Y" uniqKey="Cao Y">Y. Cao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hermann, T" uniqKey="Hermann T">T. Hermann</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Russie</li><li>Égypte</li></country></list><tree><country name="Russie"><noRegion><name sortKey="Shah Mahmud, Raihan" sort="Shah Mahmud, Raihan" uniqKey="Shah Mahmud R" first="Raihan" last="Shah Mahmud">Raihan Shah Mahmud</name></noRegion><name sortKey="Ilinskaya, Olga" sort="Ilinskaya, Olga" uniqKey="Ilinskaya O" first="Olga" last="Ilinskaya">Olga Ilinskaya</name><name sortKey="Romanova, Yulia" sort="Romanova, Yulia" uniqKey="Romanova Y" first="Yulia" last="Romanova">Yulia Romanova</name><name sortKey="Ulyanova, Vera" sort="Ulyanova, Vera" uniqKey="Ulyanova V" first="Vera" last="Ulyanova">Vera Ulyanova</name></country><country name="Allemagne"><noRegion><name sortKey="Muller, Christin" sort="Muller, Christin" uniqKey="Muller C" first="Christin" last="Müller">Christin Müller</name></noRegion><name sortKey="Mostafa, Ahmed" sort="Mostafa, Ahmed" uniqKey="Mostafa A" first="Ahmed" last="Mostafa">Ahmed Mostafa</name><name sortKey="Pleschka, Stephan" sort="Pleschka, Stephan" uniqKey="Pleschka S" first="Stephan" last="Pleschka">Stephan Pleschka</name></country><country name="Égypte"><noRegion><name sortKey="Mostafa, Ahmed" sort="Mostafa, Ahmed" uniqKey="Mostafa A" first="Ahmed" last="Mostafa">Ahmed Mostafa</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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